Abstract #0832

Common coordinate framework of neonate macaque brain based on ultra-high-resolution diffusion MRI

Juri Kim^1,2, Tianjia Zhu^1,2, Fengxia Wu^3,4, Andre Sousa⁵, Jon Levine⁵, Arnold Kriegstein⁶, and Hao Huang^1,4

¹Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, ²Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Anatomy and Neurobiology, Shandong University, Jinan, China, ⁴Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ⁵Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, United States, ⁶Department of Neurology, University of California San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Normal Development, Normal development, large animals-nonhuman primates, ultra-high resolution, diffusion MRI, common coordinate framework

Motivation: Macaque brain structures change dramatically from birth to adulthood. However, there is no neonate macaque brain common coordinate framework (CCF) serving as neuroanatomical reference for mapping genetic, cellular, and molecular information.

Goal(s): To establish an ultra-high-resolution CCF for macaque brain at birth.

Approach: We acquired ultra-high resolution diffusion MRI (dMRI) of neonate macaque brain and annotated fine neuroanatomical structures and investigated white matter tract development from neonate to adult macaque through dMRI-based tractography.

Results: The established neonate macaque brain CCF is featured with 0.2mm isotropic ultra-high diffusion imaging resolution, comprehensive gray and white matter labels, and a coordinate framework.

Impact: This first neonate macaque brain CCF with 0.2mm isotropic ultra-high diffusion imaging resolution serves as neuroanatomical reference, enables mapping genetic, cellular, and molecular information, and provides image templates, laying the foundation for the brain development and evolution discoveries.

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