Abstract #0833

Functional connectivity of motor resting-state networks in infants who are HIV-exposed uninfected in a South African birth cohort study

Simone Rose Williams^1,2, Joanah Madzime^1,2, Michal R Zieff^1,2, Niall Bouke³, Lauren Davel^1,2, Layla E Bradford^1,2, Reese Samuels^1,2, Chloë A Jacobs^1,2, Sadeeka Williams^1,2, Nwabisa Mlandu^1,2, Tracy Pan^1,2, Zamazimba Madi^1,2, Thandeka Mazubane^1,2, Tembeka Mhlakwaphalwa^1,2, Khanyisa Nkubungu^1,2, Bokang Methola^1,2, Marlie Miles^1,2, Jessica E Ringshaw^1,2,3, Daniel C Alexander⁴, Derek K Jones⁵, Steven C. R Williams ³, and Kirsten A Donald^1,2

¹Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa, ²Neuroscience Institute, Cape Town, South Africa, ³King's College London, London, United Kingdom, ⁴University College London, London, United Kingdom, ⁵Cardiff University, Wales, United Kingdom

Synopsis

Keywords: Neuro, Brain Connectivity, Neurodevelopment, Paediatrics, HIV exposure, resting state fMRI

Motivation: Children who are HIV-exposed uninfected present with an increased risk of adverse motor developmental outcomes. Little is known about the pathophysiological mechanisms governing these outcomes.

Goal(s): This study aimed to investigate functional connectivity within the motor resting-state network in infants who are HIV-exposed uninfected using resting-state functional MRI.

Approach: We used Group Independent Component Analysis to identify the motor resting-state network and multivariate linear regression was used to compare its functional connectivity between groups.

Results: Infants who are HIV-exposed uninfected showed significant connectivity alterations in 26 connections within the motor resting-state network when compared to infants who are unexposed.

Impact: Functional connectivity alterations observed in the motor resting-state network could be linked to adverse motor developmental outcomes in children who are HIV-exposed uninfected. Future research will look at associations between functional connectivity of motor resting state network and motor development.

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