Keywords: Liver, Quantitative Imaging
Motivation: Hepatic tissue architecture and water-fat content change concurrently with liver disease progression. Simultaneous measurement of water-specific T1 (T1-W) and proton density fat fraction (PDFF) can serve as a quantitative metric for assessment of liver disease.
Goal(s): To develop and validate a Look-Locker multi-echo Dixon (LLmDIXON) technique to simultaneously measure T1-W and PDFF in a single breath-hold.
Approach: Simultaneous T1-W and PDFF measurements were obtained using LLmDIXON and reference sequences in a phantom (0-40 % PDFF) and four volunteers (4.0-18.2% PDFF).
Results: The LLmDixon-based T1-W and PDFF values agreed with simulations and reference sequences in a phantom, and provided comparable PDFF values in volunteers.
Impact: LLmDixon provides simultaneous measurement of water-specific T1 and PDFF in a single 15s breath hold. This technique has the potential to characterize liver disease, where both cellular architecture and fat content can concurrently change as disease progresses.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords