Keywords: Task/Intervention Based fMRI, fMRI (task based)
Motivation: While responses to feedforward inputs have been well-observed in layer-specific fMRI studies, our understanding of responses to feedback projections within the ongoing functional processing remains limited.
Goal(s): Our study aimed to investigate how synaptic onset and strength contribute to specificity of laminar fMRI responses.
Approach: We performed the ultrahigh resolution CBV-weighted laminar fMRI by modulating thalamocortical and corticocortical projections with stimulus onset asynchrony in mice.
Results: We observed that the laminar response is highly sensitive to the strength of synaptic inputs, shifting from early to later input sites with increased strength.
Impact: Laminar CBV responses are highly regulated by micro-vessels coupled with earlier synaptic input activity, but potentially driven by the most synchronous activity within neural circuits.
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