Abstract #0893

Distinct laminar neurovascular and metabolism responses across eccentricity revealed by multi-contrast visual fMRI at 7T

Xingfeng Shao¹, Fanhua Guo¹, Jung Hwan Kim², David Ress³, Chenyang Zhao¹, Qinyang Shou¹, Kay Jann¹, and Danny J.J. Wang¹

¹Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ²Vivian L. Smith Department of Neurosurgery, UTHealth Houston Medical School, Houston, TX, United States, ³Department of Neuroscience, Baylor College of Medicine, Houston, TX, United States

Synopsis

Keywords: Task/Intervention Based fMRI, High-Field MRI, Arterial spin labeling, cortical layers, calibrated fMRI, CMRO2, negative BOLD

Motivation: To better understand the complex interplay between neurovascular responses and metabolism.

Goal(s): The goal was to develop a multi-contrast laminar fMRI tool to concurrently measure CBF, CBV, BOLD, and CMRO₂ signals.

Approach: We employed a novel pulse sequence to simultaneously acquire ASL CBF, VASO CBV, and T2-BOLD signals at a high spatial resolution of 7T. We also incorporated a calibrated fMRI approach (Davis model) to calculate CMRO₂, using parameters estimated from breath-hold induced hypercapnia.

Results: We found distinct neurovascular and metabolic responses across cortical layers and eccentricities in response to a ring-shaped visual stimulus.

Impact: Multi-contrast laminar fMRI significantly impacts neuroscientific research by providing a more comprehensive understanding of neurovascular (CBF, CBV, BOLD) and metabolic (CMRO₂) interactions across cortical layers. It opens doors for exploring complex brain functions and disorders.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.