Abstract #0895

Motor unit magnetic resonance imaging to assess muscle twitch dynamics in mitochondrial disease after an exercise programme.

Matthew Birkbeck^1,2, Mathew Elameer^1,3, Linda Heskamp¹, Jane Newman^1,4,5,6, Renae Stefanetti^1,4,5,6, Isabel Barrow^1,4,5,6, Gráinne Gorman^1,4,5,6, Ian Schofield¹, Julie Hall³, Andrew Blamire¹, and Roger Whittaker¹

¹Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom, ²Northern Medical Physics and Clinical Engineering, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, ³Department of Neuroradiology, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, ⁴Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, United Kingdom, ⁵National Institute for Health and Care Research Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom, ⁶NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, United Kingdom

Synopsis

Keywords: Functional/Dynamic, Muscle, Genetic Diseases

Motivation: Changes to muscle twitch dynamics are overlooked in trials assessing resistance exercise in primary mitochondrial myopathies (PMM).

Goal(s): Motor unit MRI to measure twitch dynamics in PMM participants before and after a 12-week exercise programme.

Approach: Voxel-wise measurements of rise time (T_rise), contraction time (T_contract) and half-relaxation time (T_half-relax) in the tibialis anterior in 10 controls and 9 PMM participants. PMM participants scanned twice, before and after a 12-week exercise programme.

Results: T_contract of the tibialis anterior was significantly longer in PMM participants post exercise; T_rise, T_half-relax demonstrated no change. In participants who had the highest adherence to exercise T_contract increased the most.

Impact: Motor unit MRI (MUMRI) detected slower muscle contraction times in primary mitochondrial myopathies post resistance exercise programme. This may evidence increased numbers of type-I fibres post-exercise. MUMRI could be used to measure changes in muscle twitch dynamics in neuromuscular diseases.

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