Abstract #0904

Connectome 2.0: Performance evaluation and initial in vivo human brain diffusion MRI results

Gabriel Ramos-Llordén¹, Peter Dietz², Mathias Davids¹, Hong-Hsi Lee¹, Yixin Ma¹, Mirsad Mahmutovic³, Alina Scholz³, Hansol Lee¹, Chiara Maffei¹, Anastasia Yendiki¹, Berkin Bilgic¹, John E. Kirsch¹, Daniel J. Park¹, Bryan Clifford⁴, Wei-Ching Lo⁴, Stefan Stocker², Jasmine Fischer², Elmar Rummert², Andreas Krug², Andreas Potthast², Thomas Benner², Rebecca Ramb², Peter J. Basser⁵, Thomas Witzel⁶, Lawrence L. Wald¹, Bruce R. Rosen¹, Boris Keil^3,7, and Susie Y. Huang¹

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, ²Siemens Healthineers, Erlangen, Germany, ³Institute of Medical Physics and Radiation Protection, Mittelhessen University of Applied Sciences, Giessen, Germany, ⁴Siemens Medical Solutions USA, Boston, MA, United States, ⁵Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States, ⁶Q Bio Inc, San Carlos, CA, United States, ⁷Department of Diagnostic and Interventional Radiology, University Hospital Marburg, Philipps University of Marburg, Marburg, Germany

Synopsis

Keywords: Gradients, Gradients, Diffusion Acquisition, Neuro

Motivation: Current human MR scanners cannot resolve the full range of length scales needed to study the brain's microscopic and mesoscopic structure.

Goal(s): To construct and validate the next-generation human connectomics and microstructure MRI scanner known as Connectome 2.0.

Approach: The 3T Connectome 2.0 scanner incorporates a peripheral nerve stimulation-optimized asymmetric head gradient driven by dual gradient power amplifiers. Custom-built high-sensitivity 72-channel (in vivo imaging) and 64-channel (ex vivo imaging) receive coils were integrated.

Results: The Connectome 2.0 scanner achieves G_max=500 mT/m and SR_max=600 T/m/s, demonstrates 2x improved SNR for diffusion MRI over Connectome 1.0, and enables high-resolution tractography.

Impact: The Connectome 2.0 scanner will allow the exploration of new microstructure properties and connectional anatomy in the living human brain with unprecedented spatial and diffusion resolution.

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