Keywords: Non-Proton, Non-Proton
Motivation: To perform 23Na MRI to study dynamic studies of changes in tissue sodium concentration in-vivo.
Goal(s): To demonstrate the application of NOise Reduction with DIstribution Corrected (NORDIC) PCA denoising to 23Na MRI data.
Approach: Dynamic timeseries of 23Na GRE data and NORDIC denoising to validate measurement of a known change in sodium concentration in a phantom, and dynamic changes in calf muscle in response to exercise.
Results: NORDIC PCA denoising allows detection of the temporal change in sodium in a phantom with good spatial resolution. This is applied to study the dynamics of sodium changes in muscle in response to exercise.
Impact: NOise Reduction with DIstribution Corrected (NORDIC) PCA denoising provides the potential to improve low SNR 23Na MRI measures to study dynamic changes in sodium on a spatially resolved level. Here, applied to study 23Na changes in calf muscle on exercise.
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