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Abstract #0930

3D whole brain mapping of creatine kinase metabolic rate using 31P-MR fingerprinting.

Mark Stephan Widmaier1,2, Antonia Kaiser1, Ying Xiao1,3, Zhiwei Huang1,4, Yun Jiang5, Song-I Lim6, Daniel Wenz6, and Lijing Xin6
1Animal imaging and technology core, CIBM Center for Biomedical Imaging, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, 2Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Lausanne, Switzerland, 3Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 4Laboratory for Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 5Department of Radiology, Case Western Reserve University, Cleveland, Cleveland, OH, United States, 6Animal imaging and technology core, CIBM Center for Biomedical Imaging, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

Synopsis

Keywords: MR Fingerprinting, MR Fingerprinting, 31P, MRF, creatine kinase rate, kCK, MRSI, 7T

Motivation: Using 31P MRS combined with magnetization transfer (MT) experiments including saturation transfer or inversion transfer to assess chemical exchange rate of creatine kinase (kCK) in the human brain are time-consuming and limited to 1D-acquisitions.

Goal(s): Acquiring a 3D whole brain kCK map.

Approach: In this abstract, we introduce an advanced, fast 3D-31P-MRF sequence for the human brain at 7T.

Results: The novel 3D-31P-MRF approach is feasible for whole brain mapping of kCK, enabling the investigation of region-specific energy metabolism under various pathological conditions.

Impact: Using the novel 3D-31P-MR Fingerprinting approach for whole brain mapping of kCK enables us to investigate region-specific energy metabolism under various pathological conditions and may enhance our understanding of the underlying molecular and metabolic processes.

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Abstract Presentation Video

Keywords