Keywords: Microstructure, Diffusion/other diffusion imaging techniques, Diffusion modeling, Quantitative imaging, Tissue characterization
Motivation: This study assesses the Neurite Exchange Imaging (NEXI) microstructure model in human cortex using clinical MRI data, addressing the model's clinical applicability.
Goal(s): How meaningful, robust, and reproducible are microstructural properties in the human cortex estimated using the NEXI diffusion model on clinical data?
Approach: Scan-rescan clinical data from six volunteers were collected and processed. NEXI was estimated and compared to expected cortical distributions and to the myelin water fraction distribution.
Results: NEXI provided robust, biologically plausible results and maintained inter-subject sensitivity and intra-subject reproducibility. A significant correlation between exchange time and myelin water fraction supports the relationship between membrane permeability and myelination.
Impact: We successfully estimate the Neurite Exchange Imaging (NEXI) model on clinical MRI data and report a strong correlation between the estimated exchange time, a proxy for membrane permeability, and the Myelin Water Fraction in the human cortex.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords