Keywords: Microstructure, Spinal Cord, Spinal cord; soma; microstructure; modeling; diffusion
Motivation: Multicompartment models of diffusion MRI have proven valuable in the brain.
Goal(s): However, application of these models in the spinal cord (SC) remains relatively understudied.
Approach: Here, we address challenges related to acquisition and image processing in order to apply the Soma and Neurite Density Imaging (SANDI) model in the human SC in 11 healthy subjects.
Results: We show that SANDI captures differences between white and gray matter tissue types and across the functionally relevant white matter pathways and gray matter architectures and has the potential to act as a biomarker for biomedical applications.
Impact: We show that the Soma and Neurite Density Imaging (SANDI) diffusion model is a feasible method to characterize both white and gray matter tissue microstructure of the in vivo human spinal cord on clinical scanners.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords