Keywords: Alzheimer's Disease, Alzheimer's Disease
Motivation: The decomposed high-frequency conductivity (HFC) into extra-neurite and intra-neurite components to calculate compartmental conductivities has not been applied to any neurological conditions.
Goal(s): To investigate how the separated extra-neurite conductivity (EC) and intra-neurite conductivity (IC) were reflected in Alzheimer’s disease (AD) patients and to evaluate the association between compartmental conductivities and cognitive decline
Approach: A total 66 patients included in 20 AD patients, 25 amnestic MCI patients, and 21 controls were scanned with a multi-echo turbo spin-echo and multi-shell diffusion tensor EPI sequences.
Results: The EC value was higher in patients with AD than others and decreased with increasing K-MMSE scores.
Impact: The EC value might be used as an imaging biomarker for helping to monitor cognitive function.
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