Abstract #0969

Visual deficits in a late-stage Parkinson’s Disease mouse model revealed by functional MRI and validated by C-FOS expression and CBF measurements

Ruxanda Lungu Baião¹, Francisca Fernandes¹, Sara Monteiro², Patricia Figueiredo², Tiago Fleming Outeiro³, and Noam Shemesh¹

¹Pre clinical MRI, Champalimaud Foundation, Lisboa, Portugal, ²Department of Bioengineering, Instituto Superior Técnico – Universidade de Lisboa, Institute for Systems and Robotics, Lisbon, Portugal, ³Department of Experimental Neurodegeneration, University of Göttingen, Gottingen, Germany

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease

Motivation: The involvement of the brain’s sensory systems in PD is poorly understood and visual deficits are often a complex and underappreciated aspect of the disease.

Goal(s): The goal of this study is to study the visual deficits in the PD mouse line by using fMRI, C-FOS expression and CBF.

Approach: Here we report aberrations in BOLD-fMRI responses along the visual pathway in mouse model of PD and validate via C-FOS protein expression and ASL.

Results: Our findings revealed decreased activity in the visual areas, decreased C-FOS confirmed the neural origin, and the ASL excluded any vascular differences that could alter the fMRI signals.

Impact: Many individuals with PD experience a decline in visual acuity. Thus, understanding and addressing visual deficits in Parkinson's disease is crucial for improving the overall well-being and daily functioning of individuals living with this condition.

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