Keywords: Multiple Sclerosis, Neurodegeneration, High-Field MRI, Diffusion Modelling, Tissue Characterization
Motivation: Cortical lesions are linked to irreversible cortical atrophy as well as cognitive impairment in multiple sclerosis. High-gradient diffusion MRI is sensitive to the microstructural substrate of neurodegeneration in multiple sclerosis.
Goal(s): To identify in-vivo patterns of cell body density alterations, quantified by advanced diffusion MRI, in and surrounding focal cortical demyelination in people with multiple sclerosis.
Approach: The intra-cellular signal fraction, reflective of cell body density, was compared between cortical lesions, perilesional and normal-appearing cortex.
Results: Multiple sclerosis-related decreases in intra-cellular signal fraction were seen in cortical lesions compared to perilesional and normal-appearing cortex.
Impact: High-gradient diffusion MRI has the potential to identify cortical cell body loss in-vivo, potentially attributable to focal demyelination, relevant for cognition.
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