Keywords: Neuroinflammation, Brain Connectivity, Cerebral Metabolic Rate of Oxygen
Motivation: Obstructive sleep apnea (OSA) is a common disorder predisposing patients to heart disease, stroke, and cognitive dysfunction.
Goal(s): To gain insights into the association between brain metabolism and changes in upper airway architecture during spontaneous apneas during sleep in the scanner.
Approach: A time-resolved pulse sequence was designed that yields neurometabolic parameters and airway anatomy at 6-second temporal resolution, along with EEG monitoring during a 90-minute scan.
Results: Data demonstrate associations between transient airway architectural changes and brain vascular-metabolic alterations, notably a steep drop in cerebral metabolic rate of oxygen (CMRO2) during sleep and following apneic events, providing new insight into the disorder.
Impact: Understanding the acute structural and neurometabolic consequences of apneic events in obstructive sleep apnea will provide new insight into the disease and provide a method to evaluate the response to treatment.
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