Abstract #0980

Neuronal and Cerebrovascular Response to tDCS in Multiple Sclerosis: A Simultaneous tDCS-MRI Study

Marco Muccio^1,2, Giuseppina Pilloni³, Lauren Krupp³, Abhishek Datta⁴, Marom Bikson⁵, Leigh Charvet³, and Yulin Ge^1,2

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York City, NY, United States, ²Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York City, NY, United States, ³Neurology, New York University Grossman School of Medicine, New York City, NY, United States, ⁴Research and Development, Soterix Medical Inc, Woodbridge Township, NJ, United States, ⁵Biomedical Engineering, City College of New York, New York City, NY, United States

Synopsis

Keywords: Multiple Sclerosis, Metabolism, cerebral metabolism, neural stimulation. blood flow

Motivation: The cerebral metabolic underpinnings of tDCS, both during the stimulation itself and as result of repeated sessions are still not fully understood.

Goal(s): To quantify the immediate tDCS effects (simultaneous) using real-time tDCS-MRI and treatment-related effects (cumulative after repeated sessions) in multiple sclerosis (MS) patients.

Approach: MS patients had tDCS-MRI performed at baseline and after 20 tDCS treatment sessions. Imaging measurements were acquired pre-, during- (2.0mA left frontal anodal) and post-tDCS.

Results: During tDCS, at baseline, we observed a 7.6% increase in cerebral metabolic rate of oxygen (CMRO₂). tDCS-treatment induced a 9.6% increase of the pre-tDCS CMRO₂ levels.

Impact: The significant increase in neuronal metabolism following both real-time and repeated tDCS treatment in MS patients offers valuable insights into the biophysiological mechanisms regarding acute and cumulative tDCS effects, informing future clinical applications in MS and other neurodegenerative diseases.

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