Abstract #0984

Advancing Estimation of Microvascular Perfusion in the Choroid Plexus through Inversion Recovery Prepared IVIM MRI

Chenyang Li^1,2,3, Zhe Sun^1,2,3, Eric E. Sigmund^1,2, Jiangyang Zhang^1,2, and Yulin Ge^1,2

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ²Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ³Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Neurofluids, Diffusion/other diffusion imaging techniques, IVIM, diffusion, choroid plexus

Motivation: Measuring vascular perfusion in the Choroid Plexus (ChP) is challenging due to its smaller size and the pronounced partial volume effects from CSF.

Goal(s): To improve blood perfusion assessment of ChP utilizing Inversion recovery (IR) prepared IVIM imaging.

Approach: Higher in-plane resolution (1.5x1.5mm²) IVIM diffusion MRI data with and without the IR preparation were acquired. The signal was analyzed using inverse Laplace transform (ILT) to estimate diffusion compartments within ChP for IVIM-derived perfusion fraction analysis.

Results: ILT analysis of IR-prepared IVIM revealed three diffusion compartments within the ChP and reported higher perfusion fraction observed in IR-prepared IVIM versus IVIM without IR-preparation.

Impact: This study provides a novel approach to investigate the microvascular perfusion in Choroid Plexus (ChP) with CSF signal removed. IR preparation does not completely remove the free-diffusion compartment but increases the microvascular perfusion fraction estimation in ChP.

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