Abstract #0983

Non-contrast MRI assessment of CSF drainage into superior sagittal sinus

Dengrong Jiang¹, Jie Song², Yifan Gou³, Zhiyi Hu³, Wen Shi³, Zixuan Lin⁴, Abhay Moghekar⁵, and Hanzhang Lu¹

¹Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, United States, ²Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, ³Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, United States, ⁴Department of Biomedical Engineering, Zhejiang University, Hangzhou, China, ⁵Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Neurofluids, Neurofluids

Motivation: The absorption of CSF into the superior-sagittal-sinus (SSS) is an important CSF drainage pathway and has been implicated in brain disorders like Alzheimer’s disease and idiopathic-intracranial-hypertension. However, we still lack non-invasive and non-contrast techniques to evaluate this CSF-venous drainage system.

Goal(s): To develop a novel non-contrast MRI technique to assess the CSF drainage into the SSS.

Approach: We propose to magnetically label the CSF spins and use a control-label subtraction to isolate signals from the CSF spins that have been absorbed into SSS.

Results: In all subjects, we observed considerable signals from absorbed CSF spins in frontal SSS. Test-retest experiments demonstrated good reproducibility.

Impact: We have proposed a novel non-contrast MRI technique to assess the drainage of CSF into the superior-sagittal-sinus, which may address an important technical gap in evaluating the circulation of CSF.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.