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Abstract #0982

Neuronal activity can drive cerebrospinal fluid flux via brain blood volume

Benedikt Zott1,2,3, Juliana Zimmermann1,3,4, Clara Boudriot1, Christiane Eipert1, Gabriel Hoffmann1, Rachel Nuttall1,4, Sebastian Schneider1,3, Lena Schmitzer1, Jan Kufer1, Stefan Kaczmarz1, Dennis Martin Hedderich1, Andreas Ranft4, Daniel Golkowski5,6, Rüdiger Ilg5,7, Gerhard Schneider4, Josef Priller8,9,10, Claus Zimmer1, Christine Preibisch1,3, and Christian Sorg1,3,8
1Department of Neuroradiology, Technical University of Munich, School of Medicine and Health, Munich, Germany, 2TUM Institute for Advanced Study, Munich, Germany, 3TUM-Neuroimaging Center, Technical University of Munich, School of Medicine and Health, Munich, Germany, 4Department of Anesthesiology and Intensive Care, Technical University of Munich, School of Medicine and Health, Munich, Germany, 5Department of Neurology, Technical University of Munich, School of Medicine and Health, Munich, Germany, 6Department of Neurology, University of Heidelberg, Heidelberg, Germany, 7Department of Neurology, Asklepios Stadtklinik Bad Tölz, Bad Tölz, Germany, 8Deparment of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine and Health, Munich, Germany, 9Psychiatry, Charité - Universitätsmedizin Berlin and DZNE, Berlin, Germany, 10University of Edinburgh and UKI DRI, Edinburgh, United Kingdom

Synopsis

Keywords: Neurofluids, Neurofluids

Motivation: A driver of macroscopic CSF flux across ventricles and basal cisternae is hypothesized to be global cerebral blood volume, possibly induced by changes in brain-wide neuronal activity.

Goal(s): We intended to test this hypothesis experimentally in healthy human subjects.

Approach: We performed two experiments: (1) electro-encephalography and functional MRI (fMRI) during burst-suppression anesthesia, and (2) arterial spin labeling and fMRI during transient hypercapnic challenges in wakefulness.

Results: Changes in brain blood volume, induced by neuronal activity switches during burst-suppression or brain blood flow during hyper-normocapnia transitions, cause fMRI signal changes in the basal cisternae which represent CSF flux from or into the brain.

Impact: Two distinct experiments revealed a consistent and direct coupling between macroscopic CSF flux and brain blood volume, which can be induced by changes in global neuronal activity. This may contribute to perivascular CSF flow and facilitate brain waste clearance.

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