Keywords: Neurofluids, Neurofluids
Motivation: A driver of macroscopic CSF flux across ventricles and basal cisternae is hypothesized to be global cerebral blood volume, possibly induced by changes in brain-wide neuronal activity.
Goal(s): We intended to test this hypothesis experimentally in healthy human subjects.
Approach: We performed two experiments: (1) electro-encephalography and functional MRI (fMRI) during burst-suppression anesthesia, and (2) arterial spin labeling and fMRI during transient hypercapnic challenges in wakefulness.
Results: Changes in brain blood volume, induced by neuronal activity switches during burst-suppression or brain blood flow during hyper-normocapnia transitions, cause fMRI signal changes in the basal cisternae which represent CSF flux from or into the brain.
Impact: Two distinct experiments revealed a consistent and direct coupling between macroscopic CSF flux and brain blood volume, which can be induced by changes in global neuronal activity. This may contribute to perivascular CSF flow and facilitate brain waste clearance.
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