Abstract #0981

Blood and CSF Dynamics During One Cardiac Cycle in the Healthy Brain Measured with Cine Phase-Contrast MRI

Marco Muccio^1,2, Zhe Sun^1,2,3, Chenyang Li^1,2,3, David Chu⁴, Lawrence Minkoff⁴, and Yulin Ge^1,2

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York City, NY, United States, ²Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York City, NY, United States, ³Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York City, NY, United States, ⁴FONAR Corporation, Melville, NY, United States

Synopsis

Keywords: Neurofluids, Brain

Motivation: Quantitative analysis of blood and CSF flow dynamics is vital to understand the intracranial pulsating fluid movement environment and its role in brain homeostasis.

Goal(s): To characterize the correlation between blood (arterial/venous) and CSF flow within one cardiac cycle.

Approach: Flow dynamic measurements in neck arteries and veins, cervical CSF (CSFc) and CSF in the aqueduct of Sylvius (CSFAq) were obtained using cine phase-contrast MRI from 18 healthy volunteers.

Results: Net blood and CSFc flow wave curves depict a compensatory mechanism resulting in balance of total fluid inflow and outflow. CSFAq flow patterns mimic CSFc ones with some temporal delay.

Impact: Understanding how blood and CSF flow influence each other in healthy subjects provides a reference frame to investigate alterations caused by neurological disease. We showed a dynamic interplay between neck blood and CSF flow at the cervical and aqueduct level.

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