Abstract #0985

Artery-pulsation dependence of the paravascular cerebrospinal fluid flow measured by dynamic diffusion tensor imaging in human brain

Guangxu Han^1,2, Yinhang Jia^1,2, Yi-Cheng Hsu³, and Ruiliang Bai^1,2

¹Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ²Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of Medicine, Hangzhou, China, ³MR Research Collaboration Team, Siemens Healthineers Ltd., Shanghai, China

Synopsis

Keywords: Neurofluids, Neurofluids, Glymphatic system

Motivation: There is still lack non-invasive methods to quantitative measure the paravascular cerebrospinal fluid (pCSF) flow speed and directions pulsations of arterial vessel .

Goal(s): To explore whether dynamic DTI_low-b could capture the artery-pulsation dependence of pCSF flow in human and how DTI_low-b metrics are modulated by artery pulsation.

Approach: Six-direction dynamic DTI_low-b was acquired simultaneously with finger pulse oximeter recording on eight subjects.

Results: Both the axial and radial diffusivity of pCSF and whole-brain white matter is increased by artery dilation. DTI_low-b signal of pCSF at b = 0 mm²/s also shows artery-pulsation dependence but lags from diffusivity changes.

Impact: The proposed dynamic DTI_low-b with ultra-long TE could potentially capture the volume and flow dynamics of MRI-visible and -invisible pCSF in artery pulsation.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.