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Abstract #0988

Extracellular Volume Change in Human Brains during Sleep: A Simultaneous Sodium (23Na) MRI and EEG Study

Xingye Chen1,2,3, Ying-Chia Lin1,2, Nahbila-Malikha Kumbella1, Simon Henin4, Zena Rockowitz5, Anli Liu4, Arjun Masurkar5, James Babb1,2, Yulin Ge1,2, Yvonne Lui1,2, and Yongxian Qian1,2
1Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, 2Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, 3Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, United States, 4Comprehensive Epilepsy Center, Department of Neurology, New York University Grossman School of Medicine, New York, NY, United States, 5Alzheimer’s Disease Research Center, Department of Neurology, New York University Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Neurofluids, Aging, Sodium MRI, EEG

Motivation: Alzheimer's disease is associated with neurotoxic amyloid-beta(Aβ) plaques. Studies in mice demonstrate that impaired cerebrospinal fluid(CSF) clearance reduces Aβ clearance by 70%. Sleep enhances CSF clearance by expanding extracellular space.

Goal(s): However, the impact of sleep on extracellular volume change remains unclear in human brains due to a lack of non-invasive technology.

Approach: To address this gap, we use sodium(23Na) MRI to measure the extracellular volume fraction in 16 healthy human brains. We monitor the sleep stage with MRI-compatible Electroencephalography(EEG).

Results: On average, a decrease in extracellular volume fraction was observed in the gray matter significantly, but not significant in the white matter.

Impact: Our research may shed light on how sleep may facilitate Aβ clearance in humans, bridging the gap between animal and human studies.

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Abstract

Keywords