Keywords: Alzheimer's Disease, Alzheimer's Disease, Glymphatic system, CSF
Motivation: The glymphatic system plays a crucial role in brain waste clearance, and dysfunction has been linked to neurodegenerative diseases like Alzheimer's Disease. Understanding this system is essential for advancing our knowledge of brain health.
Goal(s): We aim to develop a non-invasive method to assess glymphatic activity in the human brain.
Approach: We utilize a quantitative CSF measurement technique with a three-pool model and multi-echo spin-echo images.
Results: Significant variations in glymphatic activity were observed across different brain regions and found to be influenced by sleep.
Impact: Our method can potentially reveal sleep-influenced glymphatic activity variations, enabling early Alzheimer's Disease diagnosis.
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