Abstract #0993

Effect of visual stimulation on cerebrospinal fluid flow is impaired in glaucoma patients

Ji Won Bang¹, Carlos Parra¹, Kevin Yu¹, Gadi Wollstein^1,2, Joel S Schuman^1,3,4,5, and Kevin C Chan^1,6

¹Department of Ophthalmology, New York University Grossman School of Medicine, New York, NY, United States, ²Department of Biomedical Engineering, Tandon School of Engineering, New York University, New York, NY, United States, ³Wills Eye Hospital, Philadelphia, PA, United States, ⁴Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, United States, ⁵Department of Biomedical Engineering, Drexel University, Philadelphia, PA, United States, ⁶Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Neurofluids, Neurofluids

Motivation: Glaucoma is an age-related neurodegenerative disease of the visual system. Recent studies suggested that glaucoma may lead to changes in cerebrospinal fluid (CSF) dynamics, which can be influenced by neural activity. However, it remains unclear how the CSF dynamics is altered in glaucoma.

Goal(s): To test whether the impact of visual stimulation on CSF inflow is impaired in glaucoma.

Approach: We used visually-evoked BOLD fMRI responses to compare the coupling between BOLD activity and CSF inflow across healthy individuals and glaucoma patients.

Results: Our findings indicate that the influence of visual stimulation on CSF inflow decreases with glaucoma severity.

Impact: Our findings suggest that CSF inflow is altered in glaucoma. Future studies should investigate whether this reduced impact of visual stimulation on CSF inflow is due to impaired neural activity or impaired interaction between cerebrovascular activity and CSF dynamics.

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