Abstract #0995

Imaging GBCA enhancement in the periosteal and meningeal layers of dura mater using high resolution MRI at 7T

Yinghao Li^1,2,3, Yuanqi Sun^1,2,3, Adrian Paez¹, Linda Knutsson^1,4, Peter C.M. Van Zijl^1,2,3, and Jun Hua^1,3

¹F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Kreiger Institude, Baltimore, MD, United States, ²Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Neurosection, Division of MRI Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Neurofluids, Neurofluids, CSF, dura mater

Motivation: The GBCA enhancement detected in the parasagittal dura (PSD) is hypothesized to originate from the dura mater blood vessels lacking a blood-brain-barrier. The dura mater consists of two layers: periosteal and meningeal dura mater. No prior study has examined the pattern of GBCA enhancement within these layers.

Goal(s): To visualize GBCA enhancement in the periosteal and meningeal layers of dura mater in the human brain.

Approach: High-resolution black-blood and FLAIR MRI were performed at 7T.

Results: The two layers and their GBCA-enhancement could be visualized. T1 and T2* values in each layer were measured.

Impact: This work allows us investigate the relationship between GBCA-enhancement in the dura mater and GBCA-induced-signal-changes in the PSD and meningeal-lymphatic-vessels. This is of importance given that GBCA-enhanced MRI has been a gold-standard technique for investigating human brain clearance.

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