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Abstract #0994

High-field contrast-enhanced magnetic resonance imaging demonstrates cerebrospinal fluid nasal efflux dynamics in vivo

Kelley M. Swanberg1, Marios Kritsilis1, Nagesh Shanbhag1, Emily Johansson1, Jari Jukkola1, René In 't Zandt2, and Iben Lundgaard1
1Department of Experimental Medicine, Faculty of Medicine, Lund University, Lund, Skåne, Sweden, 2Bioimaging Centre, Faculty of Medicine, Lund University, Lund, Skåne, Sweden

Synopsis

Keywords: Neurofluids, High-Field MRI, Cerebrospinal fluid efflux

Motivation: The astroglia-mediated circulation of metabolites and waste between cerebrospinal fluid (CSF) and blood or lymph, recently termed the glymphatic system, is implicated in processes from autoimmunity to neurodegeneration.

Goal(s): Many details of CSF dynamics, particularly efflux routes from brain to periphery including nasal pathways as we examine here, remain to be clarified.

Approach: Here we investigate CSF efflux in living mice using 9.4-T in vivo dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).

Results: We show that gadolinium-based contrast agent injected into the cisterna magna (CM) of live mice dose-rate-dependently effluxes into the nasal mucosa in a manner affected by olfactory neuronal integrity.

Impact: Controversy surrounds the current model of CSF efflux from brain ventricles to periphery. We show with high-field DCE-MRI in live mice that nasal efflux of CSF from cisterna magna adapts to both a flow rate challenge and olfactory neuronal damage.

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