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Abstract #1003

Thin slice positive source QSM improves deep learning based paramagnetic rim detection in multiple sclerosis lesions

Ha Manh Luu1, Susan Gauthier1, Ilhami Kovanlikaya1, Yi Wang1, Pascal Spincemaille1, Mert Sisman1, and Thanh Nguyen1
1Weill Cornell Medicine, New York, NY, United States

Synopsis

Keywords: Diagnosis/Prediction, Quantitative Susceptibility mapping

Motivation: Rim lesions are important subset of chronic active MS lesions that show strong correlation to patient disability. Rim identification by experts is time consuming.

Goal(s): Develop tool for supporting the expert in Rim identification using 1 mm QSM.

Approach: We developed an automated deep learning-based network for PRL detection on thin-slice 1mm QSMp. We evaluated the improvement in performance compared with networks trained using 1mm QSM and 3mm QSMp.

Results: Use of high-resolution positive susceptibility source maps improves detection of Rim in MS patients compared to 1mm QSM and 3mm QSMp. The network does not require a precise QSM lesion mask to operate.

Impact: Using the Deep learning for detecting rim on 1mm QSMp, enabling reducing workload for human in detecting rim.

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