Abstract #1010

PRIME: Phase Reversed Interleaved Multi-Echo acquisition enables highly accelerated distortion-free diffusion MRI

Yohan Jun^1,2, Qiang Liu^2,3, Jaejin Cho^1,2,4, Xingwang Yong^1,2,5, Shohei Fujita^1,2, Susie Y Huang^1,2,6, Yogesh Rathi^2,3,7, and Berkin Bilgic^1,2,6

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, ²Department of Radiology, Harvard Medical School, Boston, MA, United States, ³Department of Psychiatry, Brigham and Women’s Hospital, Boston, MA, United States, ⁴Pediatric Imaging Research Center, Massachusetts General Hospital, Boston, MA, United States, ⁵Zhejiang University, Hangzhou, China, ⁶Harvard/MIT Health Sciences and Technology, Cambridge, MA, United States, ⁷Department of Radiology, Brigham and Women’s Hospital, Boston, MA, United States

Synopsis

Keywords: Diffusion Acquisition, Diffusion/other diffusion imaging techniques

Motivation: Current distortion-free multishot diffusion MRI (dMRI) techniques rely on interim reconstructions to estimate a fieldmap, whose quality deteriorates at high accelerations, thus precluding high-resolution imaging.

Goal(s): To develop a distortion-free acquisition that reaches high accelerations with high fidelity.

Approach: We propose PRIME, which incorporates a second echo acquired at lower resolution and acceleration, but with matching echo spacing as the first echo. This yields high-fidelity fieldmaps to be used in 10-fold accelerated scans.

Results: PRIME enables high-quality distortion-free dMRI at R_inplane×SMS=5×2 and 1mm³ resolution without prolonging the scan thanks to utilizing the dead time in gSlider RF-encoded acquisitions.

Impact: We propose a distortion-free dMRI sequence, PRIME, that reaches R_inplane×SMS=5×2 at 1mm³ resolution with high fidelity owing to its ability to estimate a high-quality fieldmap from a second echo inserted without prolonging the TR in gSlider RF-encoded acquisitions.

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