Keywords: Contrast Agents, PET/MR, Perfusion Kidney Gadolinium
Motivation: Our work is driven by the conviction that the integration of PET and MRI in molecular imaging has the potential to revolutionize diagnostic precision and patient care.
Goal(s): Enhance precision molecular imaging through the development of a unique hybrid PET/MRI perfusion probe, [18F][Gd(FL1)].
Approach: Develop a PET/MRI probe, [18F][Gd(FL1)], that is exceptionally stable, rapidly synthesized, efficiently radiolabeled, and allows simultaneous PET/MR imaging, focusing on tissue perfusion and renal filtration in preclinical models.
Results: After achieving high-yield radiosynthesis with a unique approach, our dual-modality probe showed consistent signals in both imaging modalities and was reliably quantified thanks to the combination of PET and MRI.
Impact: The first-of-its-kind hybrid PET/MR probe [18F][Gd(FL1)] can be readily and efficiently radio-synthetized and allows simultaneous PET/MR quantitative measurement of perfusion and excretion. This probe opens the path for quantifying molecular imaging probes in research and clinical practice.
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