Keywords: Contrast Agents, Contrast Agent, Neuroinflammation
Motivation: Neuroinflammation is a critical pathophysiological process implicated in the development of neurodegenerative disorders.
Goal(s): Imaging to detect, monitor, and surveil neuroinflammatory processes could profoundly improve how patients suffering neurodegenerative diseases are diagnosed and managed.
Approach: We evaluated brain imaging with the oxidatively activated contrast agent, Fe-PyC3A, as a proxy for inflammatory microglial activity in a mouse model of lipopolysaccharide(LPS)-induced neuroinflammation.
Results: Fe-PyC3A generated significantly greater enhancement in LPS-treated mice than in saline-treated controls, correlating with immunohistochemical quantification of microglial activation. Imaging using Gd-DOTA as negative control probe and NOX-2 deficient mice as loss of function control links Fe-PyC3A enhancement with reactive microglial activity.
Impact: MRI using oxidatively activated probes as a potential marker to detect and quantify neuroinflammatory processes could profoundly improve how patients suffering neurodegenerative diseases are diagnosed and managed.
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