Abstract #1048

In vivo assessment of astrocyte reactivity in patients with progressive supranuclear palsy

Kosei Hirata^1,2, Kiwamu Matsuoka¹, Kenji Tagai¹, Hironobu Endo¹, Harutsugu Tatebe¹, Maiko Ono¹, Naomi Kokubo¹, Yuko Kataoka¹, Asaka Oyama¹, Hitoshi Shinoto¹, Keisuke Takahata¹, Takayuki Obata¹, Masoumeh Dehghani³, Jamie Near^3,4, Kazunari Kawamura¹, Ming-Rong Zhang¹, Hitoshi Shimada^1,5, Hiroshi Shimizu⁵, Hiroshi Shimizu⁵, Takanori Yokota², Takahiko Tokuda¹, Makoto Higuchi¹, and Yuhei Takado¹

¹National Institutes for Quantum Science and Technology, Chiba, Japan, ²Tokyo Medical and Dental University, Tokyo, Japan, ³Sunnybrook Research Institute, Tronto, ON, Canada, ⁴University of Toronto, Tronto, ON, Canada, ⁵Niigata University, Niigata, Japan

Synopsis

Keywords: Dementia, Neuro, magnetic resonance spectroscopy, progressive supranuclear palsy, astrocyte reactivity

Motivation: Although astrocytic pathology is a pathological hallmark of progressive supranuclear palsy (PSP), the role of astrocytes in the pathophysiology of PSP is not fully understood.

Goal(s): This study aimed to evaluate astrocyte reactivity in vivo in patients with PSP.

Approach: Astrocyte reactivity was assessed by magnetic resonance spectroscopy and plasma biomarkers, which were verified via tau-PET and histopathological analysis.

Results: Our results suggest that, in the anterior cingulate cortex, astrocyte reactivity precedes pronounced tau deposition and neurodegenerative processes and modulates brain function in PSP. Elevated myo-inositol was associated with high lactate levels, suggesting a link between reactive astrocytes and brain energy metabolism changes.

Impact: This study assessed astrocyte reactivity in vivo using magnetic resonance spectroscopy and plasma biomarkers, providing insights into the involvement of astrocytes in the pathogenesis of progressive supranuclear palsy.

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