Abstract #1049

Association of Iron Deposition in Early-Stage Multiple Sclerosis Lesion with Remyelination Capacity: chi-separation imaging study

Hyeong-Geol Shin^1,2, Woojun Kim³, Hyun-soo Lee⁴, Jiwoong Kim⁵, Yoonho Nam⁶, Xu Li^1,2, Peter van Zijl^1,2, Jongho Lee⁷, and Jinhee Jang⁸

¹Radiology, Johns Hopkins University, Baltimore, MD, United States, ²Kennedy Krieger Institute, Baltimore, MD, United States, ³Neurology, Seoul St. Mary's Hospital, Seoul, Korea, Republic of, ⁴Siemens Healthineers, Seoul, Korea, Republic of, ⁵Mathematics and Statistics, University of South Florida, Tampa, FL, United States, ⁶Biomedical Engineering, Hankuk University of Foreign Studies, Yongin, Korea, Republic of, ⁷Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of, ⁸Radiology, Seoul St. Mary's Hospital, Seoul, Korea, Republic of

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis, 𝜒-separation

Motivation: In multiple sclerosis (MS) lesion, factors influencing myelin dynamics and future remyelination are under active investigation.

Goal(s): To assess dynamic changes of MS lesions from their early stage and explore the factors related to their future remyelination outcomes.

Approach: Longitudinal changes of MRI phenotypes in MS lesions were assessed from their early stage, particularly focusing on longitudinal alternations in diamagnetic myelin and paramagnetic iron signals using susceptibility source-separation (chi[𝜒]-separation).
.

Results: 26 lesions show remyelination and 36 did not. The hyperintensity in paramagnetic iron signal (hyper-paramagnetic sign, HPS) at early stage of lesion development was significantly associated to future remyelination.

Impact: Iron deposition sign in early-stage MS lesion, which detected by added sensitivity of 𝜒-separation to iron and myelin, can offer potential imaging marker for the impaired remyelination capability in MS pathology.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.