Keywords: Multiple Sclerosis, Multiple Sclerosis
Motivation: Multiple sclerosis (MS) lesions with different pathologic conditions could be distinguished by MRI. There may be differences in oxygen metabolism in different types of lesions.
Goal(s): To explore the oxygen metabolism of different types of lesions in MS patients by oxygen extraction fraction (OEF) both cross-sectionally and longitudinally.
Approach: The OEF map was reconstructed from a 3D multi-echo gradient echo scan. White matter lesions were classified into four types based on contrast-enhanced T1WI and quantitative susceptibility mapping.
Results: There were differences in OEF among different types of MS lesions. The OEF in the lesion and the lesion type may change as time progresses.
Impact: This study revealed tissue damage and oxygen metabolism level in different types of MS lesions. The OEF may contribute to further understanding of the pathological mechanisms in MS lesion evolution.
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