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Abstract #1060

High Resolution R1rho Dispersion Imaging in Swine Spinal Cord: A Specimen Study

David B Wang1, Katherine Li2, Mitchell J Christiansen3,4, Alan Rivera-Garcia5, and Ping Wang3,6
1Gilbert Classical Academy, Gilbert, AZ, United States, 2Desert Vista High School, Phoenix, AZ, United States, 3Neuroimaging Innovation Center, Barrow Neurological Institute, Phoenix, AZ, United States, 4Creighton University School of Medicine, Phoenix, AZ, United States, 5Arizona State University, Phoenix, AZ, United States, 6Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States

Synopsis

Keywords: Spinal Cord, Relaxometry, T1rho dispersion

Motivation: R1rho imaging can provide novel information on dynamic processes within tissues, allowing for a more comprehensive analysis of the parameters of chemical exchange and/or intrinsic microstructure.

Goal(s): To examine the feasibility of R1rho imaging in spinal cord.

Approach: We performed high resolution R1rho imaging in the swine spinal cord of swine spine specimens.

Results: The results showed that the dispersion is measurable in both spinal white matter and gray matter, suggesting that R1rho dispersion may have potential to characterize the de/remyelination and nerve injuries/repairs in neurological disorders.

Impact: The study suggested that R1rho dispersion is measurable in spinal cord, which may have potential to characterize the de/remyelination and nerve injuries/repairs in spinal cord disorders.

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Keywords