Abstract #1061

Parkinson’s disease in the spinal cord: an exploratory study to establish T2*w, MTR and diffusion-weighted imaging metric values

Samuelle St-Onge¹, Camille Coustaury¹, Caroline Landelle², Linda Solstrand Dahlberg², Ovidiu Lungu², Julien Doyon², and Benjamin De Leener^1,3,4

¹NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montréal, Montréal, QC, Canada, ²McConnell Brain Imaging Centre, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montréal, QC, Canada, ³CHU Sainte-Justine Research Center, Montréal, QC, Canada, ⁴Computer Engineering and Software Engineering, Polytechnique Montréal, Montréal, QC, Canada

Synopsis

Keywords: Spinal Cord, Diffusion Tensor Imaging, MTR, NODDI, T2*w, Biomarkers

Motivation: Much remains unknown about the impact of Parkinson's disease on the central nervous system, particularly how it affects the spinal cord microstructure.

Goal(s): This exploratory study aims to establish DWI, MTR and T2*w metric values to explore potential morphometric alterations in the spinal cord related to Parkinson’s disease.

Approach: DWI, MTR and T2*w metrics were extracted from both Parkinson’s disease patients and healthy controls.

Results: Significant correlations were found in several regions of the spinal cord, particularly for ODI, FICVF and FA, suggesting the relevance of further studying these metrics in the spinal cord of Parkinson's disease patients.

Impact: This study is the first to establish values for MTR, T2* and DWI metrics in the spinal cord of a population with Parkinson’s disease, which could contribute to a better understanding of this disease in the central nervous system.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.