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Abstract #1088

Rapid and simplified post-processing for B0 and B1 mapping with WASABI-RADISH in the application of CEST at 7T

Mara Quach1,2, Myrte Strik2,3,4, Rebecca Glarin2, Bradford A Moffat2, David K Wright5, and Leigh A Johnston1,2
1Department of Biomedical Engineering, University of Melbourne, Parkville, Australia, 2Melbourne Brain Centre Imaging Unit, University of Melbourne, Parkville, Australia, 3Spinoza Centre for Neuroimaging, Royal Netherlands Academy of Sciences, Amsterdam, Netherlands, 4Department of Computational Cognitive Neuroscience & Neuroimaging, Netherlands Institute for Neuroscience, Royal Netherlands Acadamy of Arts and Sciences, Amsterdam, Netherlands, 5Central Clinical School, Department of Neuroscience, Monash University, Melbourne, Australia

Synopsis

Keywords: CEST / APT / NOE, CEST & MT, B1, B0, WASABI, data processing, UHF, 7T, tools

Motivation: WASABI provides high fidelity B0 and B1 maps necessary for CEST correction yet suffers from prolonged post-processing incompatible with clinical use.

Goal(s): Our goal was to design an optimisation-free method to expedite map estimations.

Approach: A direct relationship was derived between B0 and B1 and information in WASABI Z-spectra.

Results: The proposed approach accelerated post-processing by a factor of 80, with improved estimation in brain regions that are noisy and/or have unpredictable initial magnetisation.

Impact: Improvement in speed and accuracy provided by RADISH has the ability to make WASABI, and quantitative CEST at ultra-high-field in general, more reliable and clinically feasible.

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