Keywords: CEST / APT / NOE, CEST & MT
Motivation: Despite its demonstrated ability to provide biological insights into various pathologies, relayed nuclear Overhauser effect (rNOE) imaging is lengthy and biased by water T1 and semisolid MT contrast.
Goal(s): To develop a rapid rNOE quantification MR-Fingerprinting (MRF) method and validate its performance in-vivo.
Approach: An rNOE-MRF acquisition protocol was designed and employed at 7T for imaging three in-vitro tissue types and wild-type mice (n=7). Quantitative glycogen, rNOE, and semisolid MT maps were simultaneously reconstructed.
Results: In-vitro rNOE exchange parameter maps were highly correlated with ground truth (r>0.99, p<0.01, NRMSE<7%). The rNOE and MT quantitative trends in mice were in agreement with previous literature.
Impact: A quantitative molecular MR-Fingerprinting method was developed, allowing for the simultaneous extraction of rNOE and semisolid MT proton-exchange parameter maps. These in-vivo, bias-dismantled maps are expected to aid in the diagnosis and characterization of cancer, stroke, and spinal cord injury.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords