Abstract #1110

Functional MRI test-retest reliability during deep brain stimulation in Parkinson’s disease

Skyler Deutsch¹, Katelyn Vu¹, Andrea Fuentes ², Sarah Wang ³, Alastair Martin¹, Jill L. Ostrem³, Philip A. Starr⁴, Doris D. Wang⁴, Ian O. Bledsoe³, and Melanie A. Morrison ¹

¹Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States, ³Neurology, University of California San Francisco, San Francisco, CA, United States, ⁴Neurological Surgery, University of California San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Task/Intervention Based fMRI, fMRI, Deep Brain Stimulation (DBS); Neuromodulation; Reliability; Reproducibility; Test-retest

Motivation: fMRI studies are advancing DBS biomarker development, but data reproducibility is unclear.

Goal(s): To evaluate resting-state fMRI reliability in 16 patients with DBS for Parkinson’s disease.

Approach: fMRI was repeated for DBS-ON and DBS-OFF conditions. Test-retest connectomes were correlated to measure reproducibility and compared across DBS conditions and clinical parameters. Signal reproducibility around the leads was also explored.

Results: Stimulation reduced reproducibility around the leads and across multiple networks, differing by brain target. Patients with less tremor and/or more rigidity and bradykinesia, and relative lower symptom and brain response to DBS had more reproducible functional connectivity.

Impact: The results enhance our understanding of the reliability of resting-state fMRI derivatives in the presence of DBS leads and during stimulation. Realizing the reliability of these data is critical to clinical translation of fMRI-based biomarkers to improve the DBS strategy.

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