Abstract #1112

The Association of Brain Functional Network Segregation with Working Memory and Negative Symptoms in Schizophrenia

Siwei Liu¹, Bing Cai Kok¹, Gurpreet Rekhi², Mei San Ang², Jia Ming Lau¹, Jia Nee Foo³, Raymond C.K. Chan^4,5, Jimmy Lee^2,3, and Juan Helen Zhou^1,6,7

¹Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, ²Research Division, Institute of Mental Health, Singapore, Singapore, ³Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore, ⁴Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China, ⁵Department of Psychology, University of Chinese Academy of Sciences, Beijing, China, ⁶Department of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore, ⁷Integrative Sciences and Engineering Programme, National University of Singapore, Singapore, Singapore

Synopsis

Keywords: Functional Connectivity, Brain Connectivity, Schizophrenia, negative symptom, network segregation

Motivation: Empirical findings suggest that negative symptoms of schizophrenia could be improved by cognitive training regime.

Goal(s): This study seeks to (1) understand how brain network architecture supporting task performance may be related to negative symptoms and (2) whether better task performance could be linked to differences in intrinsic functional network architecture.

Approach: Schizophrenia patients underwent resting state and dual-modality N-back task fMRI scans. Network segregation was summarised using the system segregation index for each network.

Results: Functional network segregation during both rest and task was associated with negative symptom severity and task performance.

Impact: The current study highlighted the common ground of altered network segregation between negative symptoms and task performance in schizophrenia and encouraged future study on improving negative symptoms and network communication through cognitive training interventions.

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