Abstract #1118

Longitudinal resting-state network changes in treatment-resistant OCD patients following MR-guided Focused Ultrasound Capsulotomy

Conrad P Rockel^1,2, Darren L Clark^1,2, Samuel Pichardo^1,2, Fady M Girgis^2,3, Beverly L Adams⁴, Zelma HT Kiss^1,2,3, and G Bruce Pike^1,2

¹Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ²Radiology and Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ³Dept of Surgery, University of Calgary, Calgary, AB, Canada, ⁴Dept of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

Synopsis

Keywords: Task/Intervention Based fMRI, fMRI (resting state), Obsessive compulsive disorder, Focused Ultrasound, Surgery

Motivation: MR-guided focused ultrasound capsulotomy is a surgical procedure to treat intractable OCD. While demonstrating clinical success, the mechanisms of symptom decrease are poorly understood.

Goal(s): This study sought to explore how intrinsic brain networks change following surgery.

Approach: Seed-based resting state fMRI was used to analyze intrinsic networks in a group of 6 OCD patients prior to and following surgery, along with a matched control group.

Results: Prior to surgery, OCD patients showed greater connectivity within internally-focused networks, and less connectivity in those involved in external cognition. One year following surgery, these connectivity differences were substantially reduced relative to controls.

Impact: This study will appeal to neuroscientists interested in resting-state networks involved with OCD, as well as in how these networks change following a MRgFUS surgical procedure which produced substantial clinical improvement.

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