Abstract #1120

Single-timepoint dynamic functional connectivity patterns in temporal lobe epilepsy

Lucas E Sainburg^1,2, Baxter P Rogers^1,2, Catie Chang^1,2,3, Dario J Englot^1,2,3,4, and Victoria L Morgan^1,2,4

¹Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ²Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ³Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, United States, ⁴Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, United States

Synopsis

Keywords: Functional Connectivity, fMRI (resting state), Epilepsy, Functional Connectivity

Motivation: Epileptic tissue generates interictal spikes between seizures, which are used to localize the epileptic focus clinically.

Goal(s): We aimed to detect dynamic functional connectivity (FC) patterns in resting-state fMRI data that may be related to interictal spikes.

Approach: We detected whole-brain dynamic FC patterns at timepoints that had FC characteristics similar to epileptic spikes in both healthy controls and patients with temporal lobe epilepsy (TLE).

Results: We found three dynamic FC patterns, one of which occurred more in TLE than in controls and the occurrence of which was related to clinical measures of epilepsy severity.

Impact: These results suggest the potential clinical utility of fMRI-based dynamic FC to detect interictal spikes. Future studies can evaluate the correspondence of these dynamic FC patterns to interictal spikes using simultaneous electrophysiology and fMRI.

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