Abstract #1121

Investigating the Effect of Central Thalamic Deep Brain Stimulation on Sleep in Alzheimer’s Disease Model

Ching-Wen Chang^1,2, Mu-Hua Wang¹, Yi-Chen Lin¹, Chih-Yu Wang¹, Ssu-Ju Li¹, Ting-Chieh Chen¹, Yao-Wen Liang¹, Ching-Te Chen³, You-Yin Chen¹, and Sheng-Huang Lin^4,5

¹National Yang Ming Chiao Tung University, Taipei City, Taiwan, ²Biomedical Translation Research Center, Academia Sinica, Taipei City, Taiwan, ³Abbott Neuromodulation, Austin, TX, United States, ⁴Department of Neurology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, ⁵Department of Neurology, Tzu Chi University, Hualien, Taiwan

Synopsis

Keywords: Functional Connectivity, Alzheimer's Disease, intermittent theta-burst stimulation (iTBS)

Motivation: In Alzheimer's disease (AD), the neuropsychiatric inventory is strongly affected by sleep disorders, and vice versa. Central thalamic deep brain stimulation (CT-iTBS) has improved memory and altered the hypothalamic function which may impact the orexinergic system and sleep.

Goal(s): Investigating the therapeutic effect of CT-iTBS on sleep, orexinergic system, and cognitive function in AD.

Approach: Applied functional magnetic resonance imaging, electrocorticogram-electromyogram, behavioral tasks, and ELISA to assess the impact of CT-iTBS in 3xTgAD mouse model.

Results: CT-iTBS significantly improved sleep fragmentation, functional connectivity, cognitive function, and orexin receptors and concentrations in 3xTgAD mice.

Impact: We discovered that CT-iTBS may play an important role in modulating sleep, the orexinergic system, and cognitive function in AD. Improved outcomes pave the future direction of treating sleep disorders in Alzheimer's disease.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.