Abstract #1130

Imaging small intracortical blood vessels at 64 μm in-plane resolution in macaque monkey brain in vivo using a large-bore 7T MRI scanner

Jianbao Wang^1,2, Yuhan Ma³, Yipeng Liu¹, Libo Lin^1,4, Avery J. L. Berman^3,5, Saskia Bollmann⁶, Jonathan R. Polimeni^7,8,9, and Anna Wang Roe^1,2,4,10

¹Department of Neurosurgery of the Second Affiliated Hospital, Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou, China, ²MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, China, ³Department of Physics, Carleton University, Ottawa, ON, Canada, ⁴College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ⁵Institute of Mental Health Research, Royal Ottawa Mental Health Centre, Ottawa, ON, Canada, ⁶School of Electrical Engineering and Computer Science, Faculty of Engineering, Architecture and Information Technology, The University of Queensland, Brisbane, Australia, ⁷Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁸Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁹Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, ¹⁰Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, China

Synopsis

Keywords: Blood Vessels, Vessels, Ultra-high field MRI

Motivation: Hemodynamics of the cerebral cortex are shaped by vascular architecture; however, it remains challenging to study the small intracortical vascular anatomy in vivo.

Goal(s): To test whether intracortical arterioles can be detected in vivo in non-human primates at 7 Tesla using a conventional human MRI scanner, and to study the organization of arterials and venules.

Approach: After conducting time-of-flight (TOF) contrast simulations, optimized TOF-MRA images from macaques were acquired using a 7T large-bore MRI scanner with 64-μm in-plane resolution.

Results: Intracortical arterioles and venules were reliably imaged and exhibited cortical area-specific differences in distribution. Imaging times were as fast as 10 minutes.

Impact: Using a standard human 7T MRI scanner, we illustrate that micron-scale intracortical arterioles are detectable non-invasively in vivo in primates. We suggest similar methods can be used to study human microvascular organization in health and disease.

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