Abstract #1145

Three-Dimensional Balanced Steady State Free Precession Ultra-short Echo Time MRI for Multiple Contrasts Whole Brain Imaging

Xin Shen¹, Eduardo Caverzasi², Yang Yang¹, Xiaoxi Liu¹, Ari Green³, Roland Henry³, Uzay Emir^4,5, and Peder Larson¹

¹Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy, ³Neurology, University of California, San Francisco, San Francisco, CA, United States, ⁴School of Health Science, Purdue University, West Lafayette, IN, United States, ⁵Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States

Synopsis

Keywords: Pulse Sequence Design, Pulse Sequence Design

Motivation: Typical ultra-short echo time (UTE) sequences lack of meaningful contrast for long T₂ components, and lack of straightforward method to derive images with only ultra-short T₂ (uT₂) components.

Goal(s): To develop a novel high-resolution fast UTE MRI sequence, potentially for myelin imaging.

Approach: The sequence was developed based on combining balanced steady-state free precession (bSSFP) and UTE techniques, together with a 3D rosette dual-echo k-space trajectory.

Results: The sequence provides PD contrast in both echo times (TEs) and enables easy separation of uT₂ components by subtraction between two TEs, which is sensitive to MS patients’ lesions.

Impact: The fast and high-resolution (0.94 mm isotropic resolution under three minutes) dual-echo bSSFP UTE sequence provides both structural information (PD contrast) and uT2 components imaging for myelin quantification (by subtraction). It has great potential aiding diagnosis of multiple sclerosis patients.

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