Abstract #1157

Association of glymphatic and white matter impairment with outcomes of paediatric hydrocephalus after ventriculoperitoneal shunt

Cailei Zhao^1,2, YiPing OuYang³, Gongwei Zhang², Dongdong Zang⁴, Jun Xia⁵, Guohua Liang², Miaoting Ye⁶, Jingsheng Wang⁴, Yungen Gan², Yangyang Zhou², Jian Yang^1,7, and Xianjun Li^1,7

¹Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China, ²Department of Radiology, Shenzhen Children’s Hospital, Shenzhen, China, ³China Medical University-The Queen's University of Belfast Joint College, China Medical University, Shenyang, China, ⁴Department of Neurosurgery, Shenzhen Children’s Hospital, Shenzhen, China, ⁵Department of Radiology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China, ⁶Children’s Healthcare & Mental Health Center, Shenzhen Children’s Hospital, Shenzhen, China, ⁷Shaanxi Engineering Research Center of Computational Imaging and Medical Intelligence, The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, China

Synopsis

Keywords: Neuro, Brain

Motivation: Whether there exist association between glymphatic/white matter impairment and postoperative outcomes of paediatric hydrocephalus.

Goal(s): We tried to investigate the glymphatic and white matter abnormalities in paediatric hydrocephalus using MRI metrics.

Approach: Fifty-five children with hydrocephalus who underwent MRI and ventriculoperitoneal shunt surgery were prospectively enrolled. DTI metrics were analyzed.

Results: Compared with controls, DTI-ALPS index decreased before surgery and recovered after surgery. The preoperative and postoperative DTI-ALPS index and FA in association fibres could predict the short-term motor and long-term cognition outcomes, respectively.

Impact: The DTI-ALPS index and FA could be a sensitive biomarker of underlying neuroanatomical changes and developmental outcomes, which would benefit the decision-making of treatment plans.

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