Abstract #1160

Abnormal white matter development during early childhood in autism spectrum disorder

Jiaying Zhang^1,2, Yuqi Liu³, Edmund T. Rolls^4,5,6, Yuan Dai³, Shujie Geng^4,7, Lin Deng³, Zilin Chen³, Yue Zhang^4,7, Minyi Tao³, Lingli Zhang³, Tai Ren³, Jianfeng Feng^4,7, Miao Cao^4,7, and Fei Li³

¹School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, China, ²State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Key Laboratory of Brain Imaging and Connectomics, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China, ³Developmental and Behavioural Paediatric Department and Child Primary Care Department, Ministry of Education-Shanghai Key Laboratory for Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁴Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, ⁵Department of Computer Science, University of Warwick, Coventry, United Kingdom, ⁶Oxford Centre for Computational Neuroscience, Oxford, UK, Oxford, United Kingdom, ⁷Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China

Synopsis

Keywords: Neuro, Brain, Autism, Neurodevelopment

Motivation: The axon morphology underlying the evolution of Autism Spectrum Disorder (ASD) symptoms during early childhood is still enigmatic.

Goal(s): To uncover the developmental patterns of axon density in early childhood of ASD , and further explore their relationships with clinical measures in ASD.

Approach: We used a multi-shell diffusion MRI dataset of 1- to 7-year-old children (including 156 ASD , 48 developmental delay/intellectual disability and 160 Typical Development).

Results: ASD reserved three white matter clusters during early childhood as TD, but exhibited abnormal curves with various developmental stages. The development-stage-specific associations between axon density and clinical measures were elucidated in ASD.

Impact: Whilst reserving uneven spatial layouts of white matter development during early childhood as TD, ASD exhibited developmental curves with altered growth rates and distinct clinical associations in different developmental stages, elucidating potential targets for early diagnoses and interventions in ASD.

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