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Abstract #1160

Abnormal white matter development during early childhood in autism spectrum disorder

Jiaying Zhang1,2, Yuqi Liu3, Edmund T. Rolls4,5,6, Yuan Dai3, Shujie Geng4,7, Lin Deng3, Zilin Chen3, Yue Zhang4,7, Minyi Tao3, Lingli Zhang3, Tai Ren3, Jianfeng Feng4,7, Miao Cao4,7, and Fei Li3
1School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, China, 2State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Key Laboratory of Brain Imaging and Connectomics, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China, 3Developmental and Behavioural Paediatric Department and Child Primary Care Department, Ministry of Education-Shanghai Key Laboratory for Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 4Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, 5Department of Computer Science, University of Warwick, Coventry, United Kingdom, 6Oxford Centre for Computational Neuroscience, Oxford, UK, Oxford, United Kingdom, 7Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China

Synopsis

Keywords: Neuro, Brain, Autism, Neurodevelopment

Motivation: The axon morphology underlying the evolution of Autism Spectrum Disorder (ASD) symptoms during early childhood is still enigmatic.

Goal(s): To uncover the developmental patterns of axon density in early childhood of ASD , and further explore their relationships with clinical measures in ASD.

Approach: We used a multi-shell diffusion MRI dataset of 1- to 7-year-old children (including 156 ASD , 48 developmental delay/intellectual disability and 160 Typical Development).

Results: ASD reserved three white matter clusters during early childhood as TD, but exhibited abnormal curves with various developmental stages. The development-stage-specific associations between axon density and clinical measures were elucidated in ASD.

Impact: Whilst reserving uneven spatial layouts of white matter development during early childhood as TD, ASD exhibited developmental curves with altered growth rates and distinct clinical associations in different developmental stages, elucidating potential targets for early diagnoses and interventions in ASD.

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