Keywords: Cancer, Cancer
Motivation: The staging and prognosis of nasopharyngeal carcinoma (NPC) remain significant challenges, with potential correlations to the Ki-67 proliferation status.
Goal(s): To assess and analyze an ITH model based on pre-treatment synthetic MRI (SyMRI) for predicting Ki-67 status in patients with pathologically confirmed NPC.
Approach: Twenty-eight NPC patients who underwent pre-treatment SyMRI. SyMRI data were processed to generate T1, T2, and PD maps. The ITHscore, derived from quantitative parameter maps, was utilized to establish models for predicting Ki-67 status based on clinical data.
Results: The ITHscore, based on quantitative parameter maps, demonstrated promise as an imaging marker for predicting Ki-67 status in NPC.
Impact: The ITHscore derived from SyMRI holds potential as a non-invasive imaging marker for predicting Ki-67 status, which can have clinical implications in the management of NPC.
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