Keywords: Cancer, Cancer, PDAC, Pancreatic cancer, Glutamine tarnsporter
Motivation: We previously identified alterations in brain and plasma glutamine/ glutamate with cachexia that led us to downregulate the glutamine transporter, SLC1A5, in the cachexia-inducing patient derived Pa04C PDAC cells.
Goal(s): Targeting the glutamine transporter represents a promising approach to delay tumor progression and establish a novel treatment strategy in PDAC cachexia.
Approach: We performed 1H MRS to determine the metabolic changes in multiple organs of mice.
Results: We identified metabolic differences in organs of mice bearing SLC1A5 downregulated tumors compared to wild type or empty vector tumors. Our data identify SLC1A5 as a target to reduce PDAC induced cachexia and associated pathways
Impact: By detecting these visceral organ metabolic changes we identified potential metabolic pathways that can be targeted to reduce cachexia.
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