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Abstract #1172

Phase-Specific Spatiotemporal Fractal Analysis and Radiomics of Free-breathing Stress Myocardial Perfusion

Changyu Sun1,2, Senthil Kumar3, and Talissa Altes2
1Chemical and Biomedical Engineering, University of Missouri Columbia, Columbia, MO, United States, 2Radiology, University of Missouri Columbia, Columbia, MO, United States, 3Medicine-Cardiology, University of Missouri Columbia, Columbia, MO, United States

Synopsis

Keywords: Myocardium, Perfusion

Motivation: This research advances quantitative analysis of myocardial perfusion MRI, potentially enhancing the precision of coronary microvascular disease diagnosis.

Goal(s): To establish a novel spatiotemporal radiomics and fractal analysis approach, assessing myocardial perfusion patterns and complexity throughout all temporal frames of stress MRI.

Approach: Employing free-breathing stress myocardial perfusion MRI, we utilized a comprehensive pixel-by-pixel spatiotemporal feature extraction, alongside phase-specific analysis, to derive global and segmental perfusion insights.

Results: Preliminary results indicate our method's efficacy in motion correction and feature extraction, offering a new quantitative perspective on myocardial perfusion, potentially relevant for CMD assessment.

Impact: The study introduces a framework that quantitatively captures myocardial perfusion patterns, potentially paving the way for enhanced diagnostic methods in coronary microvascular disease and facilitating a more precise approach to patient assessment.

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